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Generic name: Methoblastin, Emthexate, MTX, amethopterin, Rheumatrex
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Antibodies developed in 12% of patients on adalimumab monotherapy and in 1% of patients on concurrent methotrexate. May aid in identifying patients with delayed methotrexate clearance; toxicity appears to be related at least as much to the length of time that methotrexate concentrations are elevated as to the peak concentrations achieved. Patients treated with concomitant methotrexate had a lower rate of antibody development than patients on Humira monotherapy (1% versus 12%). His only other medications were amlodipine (5 mg per day) and methotrexate (15 mg per week). It works like folic acid in the body, which helps to reduce the action and toxic effects of folic acid antagonists (eg, methotrexate). Pregnant women with psoriasis or rheumatoid arthritis should not receive methotrexate (See CONTRAINDICATIONS). In patients with psoriatic arthritis, the rate of antibody development in patients receiving Humira monotherapy was comparable to patients with rheumatoid arthritis; however, in patients receiving concomitant methotrexate the rate was 7% compared to 1% in rheumatoid arthritis. Taking methotrexate and alcohol together may increase the risk of liver injury. This indicates that NSAIDs may enhance the toxicity of methotrexate. She had been successfully treated with infliximab 3 mg/kg every 6 to 8 weeks together with methotrexate, without side effects. Cutaneous lesions partially remitted following infliximab discontinuation and methotrexate treatment.
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